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Neuronal cell death: when, why and how

L L Rubin1

  • 1Eisai London Research Laboratories Ltd, University College London, UK.

British Medical Bulletin
|January 1, 1997
PubMed
Summary
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Neuronal apoptosis, or programmed cell death, in the nervous system follows similar rules to other cells. The specific proteases activated during neuronal apoptosis depend on how the cell death process is initiated.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Apoptosis is increasingly recognized as a key process in nervous system development and disease.
  • Neuronal apoptosis shares morphological and biochemical similarities with apoptosis in other cell types.
  • Cell death can be triggered by various extracellular factors and internal signaling pathways.

Purpose of the Study:

  • To investigate the mechanisms of apoptosis in neurons.
  • To understand the role of gene transcription in neuronal cell death.
  • To identify the specific proteases involved in different modes of neuronal apoptosis.

Main Methods:

  • Investigated neuronal apoptosis triggered by survival factor withdrawal.
  • Examined transcription-independent neuronal death induced by agents like staurosporine.

Related Experiment Videos

  • Analyzed the activation of ICE family proteases in response to different death stimuli.

    • Main Results:

    • Gene transcription, particularly involving the c-jun transcription factor, is crucial for neuronal death upon survival factor withdrawal.
    • Neuronal death can also occur independently of gene transcription, as demonstrated with staurosporine.
    • Activation of ICE family proteases is common to both transcription-dependent and -independent neuronal apoptosis.
    • The specific ICE family protease activated differs depending on the mode of apoptosis initiation.

    Conclusions:

    • Neuronal apoptosis is a regulated process influenced by both transcriptional and non-transcriptional pathways.
    • The choice of ICE family protease in neuronal apoptosis is contingent on the initiating stimulus.
    • Understanding these pathways is vital for addressing nervous system development and disease.