Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis and cytotoxins

J A Hickman1, C C Boyle

  • 1School of Biological Sciences, University of Manchester, UK.

British Medical Bulletin
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Toxin lethality depends on a cell's ability to undergo apoptosis, not just damage. Cell survival depends on gene expression and environmental factors, impacting how we predict toxicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural mechanisms of mindfulness: reduced neural reactivity to social-evaluative threat accounts for mindfulness intervention effects on inflammatory gene expression.

Brain, behavior, and immunity·2026
Same author

Molecular screening to select therapy for advanced cancer?

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.

Molecular and cellular biology·2010
Same author

Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients.

Cell death and differentiation·2007
Same author

Different cell thresholds for commitment to death: a link between carcinogenesis and drug resistance.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy·2006
Same author

Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment.

Oncogene·2006

Area of Science:

  • Toxicology
  • Cell Biology
  • Molecular Biology

Background:

  • Xenobiotics can cause cell death through various mechanisms.
  • Apoptosis (programmed cell death) is a common pathway for toxin-induced cytotoxicity.
  • Toxin selectivity is complex and not solely based on damage inflicted.

Purpose of the Study:

  • To investigate the role of apoptosis threshold in determining xenobiotic toxicity.
  • To explore how cellular factors influence susceptibility to cytotoxic agents.
  • To re-evaluate the prediction of organismal toxicity based on cellular responses.

Main Methods:

  • Analysis of gene expression patterns related to apoptosis.
  • Assessment of cellular responses to various xenobiotics.
  • Evaluation of the influence of cellular environment on apoptosis induction.

Related Experiment Videos

Main Results:

  • The threshold for apoptosis is a key determinant of xenobiotic lethality.
  • Relative expression of pro- and anti-apoptotic genes influences cell death onset.
  • Cellular phenotype, stress response gene modulation, and trophic environment impact apoptosis threshold.
  • Directly measuring cellular damage does not reliably predict toxicological outcomes.

Conclusions:

  • Toxin selectivity is influenced by a cell's propensity to initiate apoptosis.
  • Predicting toxicity requires understanding dynamic cellular responses, not just static damage.
  • Cellular apoptosis threshold is a critical factor in xenobiotic toxicity and organismal response.