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Acid-sensing by carotid body is inhibited by blockers of voltage-sensitive Ca2+ channels
A Roy1, C Rozanov, R Iturriaga
1University of Pennsylvania, School of Medicine, Department of Physiology, Philadelphia 19104-6085, USA.
Brain Research
|November 28, 1997
Abstract:
The membrane potential hypothesis that the responses to hypercapnia of carotid chemosensory activity is mediated by voltage-gated Ca2+ channels was investigated by measuring directly the chemosensory output from rat and cat carotid bodies, perfused and superfused in vitro. We found that the inorganic and organic blockers of voltage-gated Ca2+ channels suppressed the hypercapnic responses, thereby supporting the membrane potential hypothesis.