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Related Experiment Videos

Differentiated thyroid cancer presenting initially with distant metastasis

A R Shaha1, J P Shah, T R Loree

  • 1Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

American Journal of Surgery
|November 28, 1997
PubMed
Summary
This summary is machine-generated.

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Distant metastases at initial diagnosis of differentiated thyroid cancer are rare but manageable, with a 43% long-term survival rate. Follicular thyroid cancer shows the highest incidence of metastatic presentation.

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Distant metastases at initial diagnosis of differentiated thyroid cancer (DTC) are uncommon.
  • Despite the rarity, appropriate management yields a notable 43% long-term survival rate.
  • This study reviews the experience of DTC patients presenting with initial distant metastatic disease.

Purpose of the Study:

  • To analyze the prognostic factors and survival outcomes of differentiated thyroid cancer patients who initially presented with distant metastases.
  • To identify specific subtypes and patient demographics associated with a higher incidence of initial distant metastatic disease.

Main Methods:

  • Retrospective analysis of 1,038 consecutive DTC patients treated at Memorial Sloan-Kettering Cancer Center (1930-1985).
  • Identified 44 patients (4%) with initial distant metastases.

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  • Utilized Kaplan-Meier method for survival curves and Cox regression for univariate and multivariate analyses.

    • Main Results:

    • Incidence of initial distant metastases was 2.3% in papillary thyroid cancer and 11% in follicular thyroid cancer.
    • Higher incidence observed in patients over 45 and with follicular thyroid carcinoma.
    • Long-term survival was 43% for patients with initial distant metastases versus 86% for those without (P < 0.001).

    Conclusions:

    • Differentiated thyroid cancer with initial distant metastases has a better long-term prognosis (43% survival) compared to other cancers.
    • Follicular thyroid cancer is associated with the highest incidence of initial distant metastatic presentation.
    • Effective initial evaluation and treatment are crucial for achieving satisfactory long-term survival in these patients.