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Published on: February 4, 2017
Simplified technetium-99m-EC clearance in adults from a single plasma sample
L Kabasakal1, A F Yapar, K Ozker
1Department of Nuclear Medicine, Cerrahpaşa Medical Faculty, Istanbul, Turkey.
Summary
Technetium-99m-EC clearance can be accurately estimated using a simplified single-sample method. This approach provides an acceptable standard error of estimation for routine clinical studies.
Area of Science:
- Nuclear medicine
- Renal physiology
Background:
- Technetium-99m-EC is a novel renal tubular agent.
- It correlates well with 131I-ortho iodohippurate (OIH) for estimating effective renal plasma flow.
Purpose of the Study:
- To evaluate the feasibility of determining Technetium-99m-EC clearance using a single plasma sample method.
- To simplify clearance determination in routine clinical practice.
Main Methods:
- Collected data from 72 subjects, including two anuric hemodialysis patients.
- Determined clearances using an open two-compartment model.
- Analyzed correlation using Tauxe's method.
Main Results:
- Clearance values ranged from 12 to 660 ml/min (mean 275 +/- 117 ml/min).
- The 54-minute plasma sample yielded the best correlation (r=0.97) and least standard error of estimation (s.e.e.=32.71 ml/min).
Conclusions:
- Technetium-99m-EC clearance can be reliably determined by a simplified single-sample method.
- This method offers an acceptable standard error of estimation for clinical use.
