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Ifosfamide-induced alteration of technetium-99m-DMSA renal parenchymal imaging
1Department of Radiology, University Hospitals of Cleveland, Ohio, USA.
Abstract:
Renal cortical imaging with 99mTc-dimercaptosuccinic acid (DMSA) has become the imaging test of choice for the diagnosis of acute pyelonephritis. An unusual uptake pattern was observed in a child receiving chemotherapy for a bladder rhabdomyosarcoma. Chemotherapy from ifosfamide produces a specific pattern of injury to the renal tubule that alters uptake of DMSA.