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Related Experiment Videos

Circumventricular organs and fever

Y Takahashi1, P Smith, A Ferguson

  • 1Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Alberta, Canada.

The American Journal of Physiology
|December 31, 1997
PubMed
Summary
This summary is machine-generated.

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The subfornical organ, but not the area postrema or OVLT, plays a key role in mediating fever responses to circulating pyrogens like lipopolysaccharide in rats.

Area of Science:

  • Neuroscience
  • Physiology
  • Immunology

Background:

  • Fever is a critical immune response to infection.
  • Circumventricular organs are brain regions lacking a blood-brain barrier, potentially sensing blood-borne signals.
  • The area postrema, subfornical organ, and organum vasculosum of the lamina terminalis (OVLT) are implicated in fever.

Purpose of the Study:

  • To investigate the specific roles of the area postrema, subfornical organ, and OVLT in mediating fever.
  • To determine if these circumventricular organs act as access points for pyrogens to induce fever.

Main Methods:

  • Rats with lesions in specific circumventricular organs (area postrema, subfornical organ, OVLT) were used.
  • Body temperature was monitored using telemetry devices.

Related Experiment Videos

  • Fever was induced by intravenous lipopolysaccharide or intracerebroventricular prostaglandin E1.

    • Main Results:

    • Lesions of the area postrema or OVLT did not affect lipopolysaccharide-induced fever.
    • Lesions of the subfornical organ significantly reduced lipopolysaccharide-induced fever.
    • Prostaglandin E1-induced fevers were unaffected by any lesions, indicating intact central thermoregulatory pathways.

    Conclusions:

    • The subfornical organ is a critical site for sensing circulating pyrogens and initiating fever.
    • Neurons within the subfornical organ likely activate downstream central pathways to generate fever.
    • The area postrema and OVLT are not primary access points for pyrogens to cause fever.