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Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters?
1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham NC 27710-3686, USA.
Chemistry & Biology
|December 31, 1997
Abstract:
The overexpression of specific transport proteins in the membrane of many cancer cells renders these cells resistant to many therapeutic drugs. Some lipid-modified cysteine compounds inhibit one drug-transporting protein, indicating the potential of developing such compounds as therapeutic agents.