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Related Experiment Videos

Changes in intestinal vascular diameter during norepinephrine vasoconstrictor escape

P H Guth, G Ross, E Smith

    The American Journal of Physiology
    |June 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    Escape from norepinephrine-induced vasoconstriction in the intestine is due to the relaxation of constricted intestinal vessels. This study in cats supports the hypothesis that initial arterial constriction followed by relaxation explains this phenomenon.

    Area of Science:

    • Physiology
    • Vascular Biology
    • Gastrointestinal Physiology

    Background:

    • Norepinephrine (NE) causes vasoconstriction, impacting intestinal blood flow.
    • The phenomenon of 'escape' from NE-induced vasoconstriction requires further elucidation.

    Purpose of the Study:

    • To test the hypothesis that escape from NE-induced vasoconstriction involves the relaxation of initially constricted intestinal vessels.

    Main Methods:

    • Utilized 18 anesthetized cats for the study.
    • Measured intestinal blood flow using an electromagnetic flow probe on the superior mesenteric artery.
    • Observed intestinal arterioles and small mesenteric arteries in vivo using microscopy and an image-splitting technique.

    Main Results:

    Related Experiment Videos

  • Norepinephrine infusion initially decreased mesenteric blood flow, followed by escape.
  • Microscopic examination revealed arterial constriction and subsequent relaxation in submucosal, muscle, and mesenteric vessels, mirroring the flow changes.
  • No arteriovenous anastomoses were observed.

    • Conclusions:

    • Findings support the hypothesis that escape from norepinephrine-induced vasoconstriction is mediated by the relaxation of previously constricted intestinal arteries.