Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fibronectin

D J Romberger

    The International Journal of Biochemistry & Cell Biology
    |July 1, 1997
    PubMed
    Summary
    This summary is machine-generated.

    Fibronectin, a key glycoprotein, is vital for cell adhesion and development. Synthetic peptides targeting fibronectin show therapeutic potential for various diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Swine barn dust stimulates CCL9 expression in mouse monocytes through PKC-delta activation.

    Environmental disease·2024
    Same author

    Organic dust-induced lung injury and repair: Bi-directional regulation by TNFα and IL-10.

    Journal of immunotoxicology·2020
    Same author

    Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.

    Genes and immunity·2017
    Same author

    Effect of elevated carbon dioxide on bronchial epithelial innate immune receptor response to organic dust from swine confinement barns.

    International immunopharmacology·2015
    Same author

    CXCR1/CXCR2 antagonist CXCL8(3-74)K11R/G31P blocks lung inflammation in swine barn dust-instilled mice.

    Pulmonary pharmacology & therapeutics·2015
    Same author

    Toll-like receptor 2 is upregulated by hog confinement dust in an IL-6-dependent manner in the airway epithelium.

    American journal of physiology. Lung cellular and molecular physiology·2008
    Same journal

    Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

    The international journal of biochemistry & cell biology·2026
    Same journal

    Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

    The international journal of biochemistry & cell biology·2026
    Same journal

    LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

    The international journal of biochemistry & cell biology·2026
    Same journal

    Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

    The international journal of biochemistry & cell biology·2026
    Same journal

    The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

    The international journal of biochemistry & cell biology·2026
    Same journal

    Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

    The international journal of biochemistry & cell biology·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Background:

    • Fibronectin is a glycoprotein involved in cell adhesion, migration, and proliferation.
    • Alternative splicing of fibronectin pre-mRNA generates multiple functional isoforms.
    • Fibronectin plays critical roles in development, inflammation, wound repair, and metastasis.

    Purpose of the Study:

    • To explore the multifaceted roles of fibronectin in biological processes.
    • To investigate the therapeutic potential of fibronectin-targeting synthetic peptides.

    Main Methods:

    • Analysis of fibronectin structure and function.
    • Utilizing a fibronectin "knock-out" mouse model to demonstrate essential roles.
    • Developing and testing synthetic peptides based on fibronectin regions.

    Related Experiment Videos

    Main Results:

    • Fibronectin's essential role in development was confirmed by early lethality in knock-out mice.
    • Synthetic peptides demonstrated ability to modulate lymphocyte binding, coronary arteriopathy, and platelet aggregation.
    • These peptides offer new therapeutic avenues for conditions like rheumatoid arthritis and cardiac transplantation.

    Conclusions:

    • Fibronectin is indispensable for normal development and influences numerous physiological and pathological processes.
    • Targeted synthetic peptides represent a promising therapeutic strategy for fibronectin-related diseases.
    • Further research into fibronectin-based therapies could yield significant clinical benefits.