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Published on: June 18, 2020
Hepatitis G virus infection in patients with bleeding disorders
J T Wilde1, M M Ahmed, K E Collingham
1West Midlands Adult Haemophilia Centre, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston.
British Journal of Haematology
|December 31, 1997
Summary
Hepatitis G virus (HGV) coinfection did not worsen liver disease severity in patients with bleeding disorders who also had hepatitis C virus (HCV). This study found no significant differences in liver disease markers between HGV/HCV coinfected and HCV-monoinfected individuals.
Area of Science:
- Hepatology
- Virology
- Hematology
Background:
- Patients with bleeding disorders are at risk for bloodborne viral infections.
- Hepatitis C virus (HCV) is prevalent in this population.
- The impact of hepatitis G virus (HGV) coinfection on liver disease severity in HCV-infected individuals with bleeding disorders requires further investigation.
Purpose of the Study:
- To determine the prevalence of hepatitis G virus (HGV) infection in patients with bleeding disorders.
- To assess the impact of HGV coinfection on the severity of liver disease in patients with hepatitis C virus (HCV) infection.
Main Methods:
- Screening of 82 patients with bleeding disorders for HGV RNA.
- Assessment of HCV infection status through antibodies and PCR.
- Liver biopsy and HCV viral load quantitation in a subset of patients.
- Comparison of histological activity index (HAI) and HCV viral titre between HGV RNA-positive and negative patients.
Main Results:
- HGV RNA was detected in 13% of patients.
- No significant difference in HAI scores between HGV RNA-positive and negative patients (P=0.07).
- No significant difference in HCV viral titre between coinfected and HCV-monoinfected patients (P=0.68).
Conclusions:
- HGV coinfection does not appear to exacerbate liver disease in HCV-infected patients with bleeding disorders.
- The prevalence of HGV in this cohort is consistent with previous studies.
- Further research may be needed to fully elucidate the clinical significance of HGV in specific patient populations.
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