Hepatitis G virus infection in patients with bleeding disorders

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Updated: Jul 24, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

J T Wilde1, M M Ahmed, K E Collingham

  • 1West Midlands Adult Haemophilia Centre, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston.

British Journal of Haematology
|December 31, 1997
PubMed

Insights

Hepatitis G virus (HGV) coinfection did not worsen liver disease severity in patients with bleeding disorders who also had hepatitis C virus (HCV). This study found no significant differences in liver disease markers between HGV/HCV coinfected and HCV-monoinfected individuals.

Area of Science:

  • Hepatology
  • Virology
  • Hematology

Background:

  • Patients with bleeding disorders are at risk for bloodborne viral infections.
  • Hepatitis C virus (HCV) is prevalent in this population.
  • The impact of hepatitis G virus (HGV) coinfection on liver disease severity in HCV-infected individuals with bleeding disorders requires further investigation.

Purpose of the Study:

  • To determine the prevalence of hepatitis G virus (HGV) infection in patients with bleeding disorders.
  • To assess the impact of HGV coinfection on the severity of liver disease in patients with hepatitis C virus (HCV) infection.

Main Methods:

  • Screening of 82 patients with bleeding disorders for HGV RNA.
  • Assessment of HCV infection status through antibodies and PCR.
  • Liver biopsy and HCV viral load quantitation in a subset of patients.
  • Comparison of histological activity index (HAI) and HCV viral titre between HGV RNA-positive and negative patients.

Main Results:

  • HGV RNA was detected in 13% of patients.
  • No significant difference in HAI scores between HGV RNA-positive and negative patients (P=0.07).
  • No significant difference in HCV viral titre between coinfected and HCV-monoinfected patients (P=0.68).

Conclusions:

  • HGV coinfection does not appear to exacerbate liver disease in HCV-infected patients with bleeding disorders.
  • The prevalence of HGV in this cohort is consistent with previous studies.
  • Further research may be needed to fully elucidate the clinical significance of HGV in specific patient populations.

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