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Updated: Jul 26, 2026
09:55
Generation and Quantitative Characterization of Functional and Polarized Biliary Epithelial Cysts
Published on: May 16, 2020
Kidney and breast cysts: a comparative study of fluids
D K Hurley1, S M Bandy, R H Glew
1Department of Physiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA.
Nephron
|January 1, 1997
Summary
Amino acids contribute osmotically to cyst fluids in autosomal dominant polycystic kidney disease (ADPKD) and breast disease (GCDB). These fluids share characteristics, with amino acids accumulating in low-sodium cysts.
Area of Science:
- Nephrology
- Endocrinology
- Biochemistry
Background:
- Autosomal dominant polycystic kidney disease (ADPKD) and gross cystic disease of the breast (GCDB) are distinct conditions characterized by cyst formation.
- The osmotic contribution of various solutes, including amino acids, to cyst fluid composition is not fully understood.
Purpose of the Study:
- To compare the amino acid composition of cyst fluids from ADPKD and GCDB.
- To determine the osmotic significance of amino acids in these cyst fluids.
Main Methods:
- Comparative analysis of cyst fluids from 18 GCDB patients and 8 ADPKD patients.
- Analysis included potassium, chloride, protein, osmolality, and amino acids (using reversed-phase high-pressure liquid chromatography).
- Fluids were grouped based on sodium concentrations.
Main Results:
- Kidney and breast cyst fluids exhibited relative isosmolality and a wide range of sodium concentrations.
- An inverse relationship was observed between sodium and potassium concentrations.
- Higher amino acid concentrations were found in low-sodium fluids, with significant correlations to blood components.
Conclusions:
- Cyst fluids in ADPKD and GCDB share compositional similarities.
- Amino acids, potentially from blood proteins, accumulate in osmotically significant amounts, particularly in low-sodium cysts.
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