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[Bilateral Wilms tumor]

A Presedo1, V Martínez Ibáñez, A Marqués

  • 1Departamento de Cirugía Pediátrica, Hospital Materno Infantil Vall d'Hebron, Barcelona.

Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica
|July 1, 1997
PubMed
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Bilateral Wilms tumor treatment in children, though rare, shows promising outcomes with renal salvage procedures and chemotherapy. These innovative approaches preserve kidney function and improve survival rates.

Area of Science:

  • Pediatric Oncology
  • Nephrology

Background:

  • Bilateral Wilms tumor is a rare pediatric kidney cancer, estimated in 5-10% of cases.
  • Associated with congenital anomalies and familial predisposition, necessitating specialized management.

Observation:

  • A retrospective analysis of 9 children with bilateral Wilms tumor (1976-1995) at Vall d'Hebron Hospital.
  • Included synchronous and metachronous tumors, genitourinary malformations, hemihypertrophy, and familial cases.
  • Treatment involved pre-operative therapy, unilateral/bilateral nephrectomy, or tumorectomy.

Findings:

  • Seven of nine patients (78%) survived, with survivors maintaining normal renal function.
  • Effective disease control and survival achieved through chemotherapy and renal salvage procedures.
  • Tumor stage and grade were critical factors in patient outcomes.

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Implications:

  • Bilateral renal salvage procedures are effective in controlling Wilms tumor without compromising renal function or survival.
  • These innovative treatments for bilateral Wilms tumor may inform strategies for unilateral cases.
  • Advances in chemotherapy enhance the efficacy of organ-sparing approaches in pediatric kidney cancer.