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Chiral resolution of flobufen by high performance liquid chromatography and capillary electrophoresis
E Tesarvá1, M Gilar, A Jegorov
1Department of Analytical Chemistry, Institute of Chemical Technology, Prague, Czech Republic.
Biomedical Chromatography : BMC
|October 6, 1997
Abstract:
The enantiomeric separation of an anti-inflammatory drug flobufen was performed on various chiral columns in liquid chromatography and by reversed phase chromatography and by capillary electrophoresis with beta-cyclodextrin as a chiral selector in the mobile phase and background electrolyte, respectively. The elution order of individual enantiomers is discussed with respect to the absolute chirality of (+/-)-flobufen determined by X-ray crystallography.