Related Experiment Videos
HL 752: a potent and long-acting antispasmodic agent
S Bal-Tembe1, D N Bhedi, A K Mishra
1Research Centre, Hoechst Marion Roussel Limited, L.B.S. Marg, Mulund, Bombay, India.
Bioorganic & Medicinal Chemistry
|July 1, 1997
Abstract:
Ester analogues of methyl-2-(4-(2-piperidinoethoxy)benzoyl)-benzoate hydrochloride (pitofenone) (2) were prepared with an aim to find a more potent and metabolically stable antispasmodic compound. The compounds were evaluated for their in vitro and in vivo antispasmodic activity, and stability to in vitro enzymatic hydrolysis. Of the compounds synthesised, HL 752 (21) showed the most potent and long-lasting antispasmodic activity and was selected as the candidate for clinical development.