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Immunostimulatory activities of mono- or diglycosylated alpha-galactosylceramides
A Uchimura1, T Shimizu, M Nakajima
1Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd, Gunma, Japan.
Bioorganic & Medicinal Chemistry
|July 1, 1997
Abstract:
We examined the effects of 2"- or 3"-monoglycosylated alpha-galactosylceramides (alpha-GalCers) and 2",3"-diglycosylated alpha-GalCers on allogeneic MLR and the proliferation of murine spleen cells. It was found that their ceramide portions greatly affect their immunostimulatory activities, and that the 3"-hydroxyl group plays a more important role in the immunostimulatory effects of alpha-GalCer derivatives than the 2"-hydroxyl group.