Related Experiment Videos
Sumatriptan does not affect vasopressin secretion in humans
T Barreca1, R Franceschini, A Cataldi
1Department of Internal Medicine, University of Genoa, Italy.
Clinical Neuropharmacology
|December 1, 1993
Abstract:
The aim of the study was to investigate the effects of a new serotoninergic drug, sumatriptan, on arginine vasopressin secretion in humans. Plasma vasopressin concentrations were determined in eight healthy volunteers, before and after administration of 6 mg of sumatriptan, or placebo. No changes in hormone levels were found after sumatriptan or placebo administration. The results suggest that in humans serotoninergic mechanisms, which modulate vasopressin secretion, do not involve the serotonin receptor activated by sumatriptan.