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[Trace elements in biological samples and immunologic parameters in environmentally exposed populations (preliminary

P Boscolo1, M Di Gioacchino, A Spanò

  • 1Centro di Medicina del Lavoro ed Ergoftalmologia, Dipartimento di Scienze, Statistica Medica, Università G. D'Annunzio, Chieti.

Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia
|January 1, 1997
PubMed
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Environmental toxins like lead and chromium impact immune cell counts in non-smoking individuals. Occupational exposure to traffic pollutants may alter immune responses, affecting lymphocyte subsets and activated cells.

Area of Science:

  • Environmental immunology
  • Toxicology
  • Immunology

Background:

  • Occupational exposure to environmental toxins can influence immune system function.
  • Previous research suggests a link between heavy metals and immune alterations.

Purpose of the Study:

  • To investigate the relationship between environmental toxin exposure (lead, chromium) and immune cell profiles.
  • To assess the impact of occupational exposure on lymphocyte subsets and activated immune cells.

Main Methods:

  • Analysis of blood lymphocyte subsets (CD4+, CD8+, NK, B cells) and activated cells (HLA-DR+) in policemen and a control group.
  • Measurement of urinary lead and chromium levels as markers of exposure.
  • Correlation analysis between toxin levels and immune parameters.

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Main Results:

  • Non-smoking policemen showed reduced CD4+ and increased CD8+ lymphocytes compared to controls.
  • Urinary lead correlated with serum IgA and specific B cell subsets in a healthy group.
  • Urinary chromium showed inverse correlations with IgA and positive correlations with NK and B cells.
  • Serum zinc and copper levels correlated with activated immune cells.

Conclusions:

  • Environmental toxins, including lead and chromium, may modulate immune responses.
  • Minerals like zinc and copper, and trivalent chromium, play a role in regulating immune cell activity.
  • Occupational exposure to traffic-related pollutants can lead to detectable immunological alterations.