Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Posttransplant growth failure in children

¹Liver Unit, Birmingham Children's Hospital NHS Trust, UK.

Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

|November 5, 1997

Summary

Liver transplantation aims to reverse malnutrition in children. However, 15-20% experience persistent growth failure due to factors like preoperative malnutrition and steroid use.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The necessity of education and hepatitis B vaccination for young people: A study of high risk behaviour for blood borne viruses in the United Kingdom.

Journal of child health care : for professionals working with children in the hospital and community·2019

Same author

A 10-year longitudinal follow-up study of a U.K. paediatric transplant population to assess for skin cancer.

The British journal of dermatology·2018

Same author

"Are these adult doctors gonna know me?" Experiences of transition for young people with a liver transplant.

Pediatric transplantation·2016

Same author

Parents in transition: Experiences of parents of young people with a liver transplant transferring to adult services.

Pediatric transplantation·2016

Same author

Selenium homocholic acid taurocholate scanning, selenium-75-labeled bile acid, a novel method for testing the function of the terminal ileum in small bowel transplant recipients: a pilot study.

Transplantation proceedings·2014

Same author

Treatment of chronic viral hepatitis C in children and adolescents: UK experience.

Archives of disease in childhood·2014

Area of Science:

Pediatric Gastroenterology and Hepatology
Transplantation Medicine
Pediatric Endocrinology

Background:

Malnutrition affects 60% of children with end-stage liver disease (ESLD).
Liver transplantation is crucial for reversing malnutrition and improving growth in these children.
Despite successful transplantation, 15-20% of pediatric recipients experience persistent posttransplant growth failure.

Purpose of the Study:

To explore the complex origins of growth failure in children following liver transplantation.
To identify key factors contributing to persistent growth deficits post-transplant.
To outline strategies for preventing posttransplant growth failure in pediatric liver recipients.

Main Methods:

Review of existing literature on pediatric liver transplantation outcomes.
Analysis of factors influencing growth, including preoperative nutritional status, immunosuppression, hepatic function, and behavioral issues.
Identification of preventative and therapeutic strategies.

Main Results:

Preoperative severe stunting (height SDS <-1) is linked to incomplete growth recovery.
Glucocorticoid therapy significantly inhibits catch-up growth; alternate-day or discontinued regimens improve growth.
Hepatic dysfunction (e.g., chronic rejection) and behavioral feeding problems also contribute to growth failure.

Conclusions:

Posttransplant growth failure in children is multifactorial, influenced by preoperative status, medications, graft function, and behavior.
Early transplantation, proactive nutritional support, and judicious steroid management are vital.
Addressing behavioral feeding issues is essential for long-term growth success post-transplantation.

Related Experiment Videos