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Sputum and pulmonary function in asthma

C K Connolly1, N K Murthy, S M Alcock

  • 1Memorial Hospital, University of Newcastle upon Tyne.

Chest
|October 23, 1997
PubMed
Summary
This summary is machine-generated.

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Chronic sputum production is linked to persistent lung obstruction, primarily in smokers, suggesting smoking as the cause, not asthma. Green sputum during asthma flare-ups may signal inflammation relevant to prognosis.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Health

Background:

  • Asthma is a chronic respiratory condition.
  • Sputum production is a common symptom in respiratory diseases.
  • The relationship between sputum and pulmonary function in asthma requires further clarification.

Purpose of the Study:

  • To investigate the association between sputum production and pulmonary function, specifically persistent obstruction, in asthma patients.
  • To determine if smoking status influences the relationship between sputum and lung function.

Main Methods:

  • A cross-sectional study was conducted in secondary care settings in north-east England.
  • 772 adult asthma patients were assessed for pulmonary function (FEV1, FVC, PEF) and sputum production.
  • Data on smoking history, atopy, and sputum characteristics were collected.

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Main Results:

  • Chronic sputum production was associated with lower best pulmonary function, particularly in smokers.
  • Green sputum during exacerbations showed an association with persistent obstruction after accounting for smoking.
  • No significant link was found between sputum and lung function in non-smokers, or between sputum color and function in univariate analysis.

Conclusions:

  • Chronic sputum production in asthma is largely attributable to smoking rather than the disease itself.
  • Green sputum during asthma exacerbations may indicate inflammation and have prognostic implications.
  • The study highlights the impact of smoking on sputum production and lung function in asthma patients.