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Peripheral-type benzodiazepine receptors

D M Zisterer1, D C Williams

  • 1Department of Biochemistry, Trinity College, Dublin, Ireland.

General Pharmacology
|September 1, 1997
PubMed
Summary
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Peripheral type benzodiazepine receptors (PBRs) are found in mammalian tissues and are distinct from central nervous system benzodiazepine sites. This review explores PBR distribution, ligands, characterization, and physiological roles.

Area of Science:

  • Pharmacology
  • Biochemistry
  • Cell Biology

Background:

  • Benzodiazepines exert pharmacological effects via GABA-A receptors.
  • A distinct class, peripheral type benzodiazepine receptors (PBRs), are present in mammalian peripheral tissues.

Purpose of the Study:

  • To review the tissue and subcellular distribution of PBRs.
  • To analyze putative endogenous ligands for PBRs.
  • To characterize PBRs pharmacologically, structurally, and molecularly.
  • To explore the physiological roles and future research directions for PBRs.

Main Methods:

  • Literature review of PBR distribution and ligands.
  • Analysis of pharmacological, structural, and molecular data.
  • Discussion of PBR physiological functions.

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Main Results:

  • PBRs exhibit widespread distribution in mammalian peripheral tissues.
  • Several endogenous ligands for PBRs have been identified.
  • Recent years have seen significant characterization of PBRs.

Conclusions:

  • PBRs represent a distinct class of benzodiazepine binding sites.
  • Understanding PBRs' physiological roles requires further investigation.
  • Future research should focus on elucidating PBR function.