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Related Experiment Video

Updated: Jan 6, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
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Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

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Renal failure after open heart surgery

J G Bhat, M C Gluck, J Lowenstein

    Annals of Internal Medicine
    |June 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Renal failure after open heart surgery is a serious complication. Factors like prolonged bypass and hypotension increase risk, with severe cases often leading to poor outcomes despite treatment.

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    Area of Science:

    • Nephrology
    • Cardiology
    • Surgical Complications

    Background:

    • Cardiopulmonary bypass is a critical component of open heart surgery.
    • Renal failure is a known, albeit uncommon, complication following cardiac procedures.
    • Understanding the incidence and risk factors for renal dysfunction post-cardiac surgery is crucial for patient management.

    Purpose of the Study:

    • To investigate the incidence and clinical course of renal failure in patients undergoing open heart surgery.
    • To identify pre-operative, intra-operative, and post-operative factors associated with the development of renal failure.
    • To assess the prognosis of renal failure following cardiopulmonary bypass.

    Main Methods:

    • Retrospective analysis of 490 patients undergoing open heart surgery.
    • Categorization of renal failure based on serum creatinine levels and oliguria.
    • Correlation analysis to identify risk factors for renal failure.

    Main Results:

    • 150 out of 490 patients (30.6%) developed renal failure post-cardiac surgery.
    • Renal dysfunction ranged from mild (creatinine < 2 mg/dl) to severe (creatinine > 5 mg/dl).
    • Prolonged cardiopulmonary bypass time, hypotension, oliguria, low output syndrome, and hemoglobinemia were significant risk factors for renal failure.

    Conclusions:

    • Renal failure is a significant complication after open heart surgery, associated with increased morbidity and mortality.
    • Early identification of risk factors and prompt management are essential for improving outcomes.
    • Severe renal failure post-cardiac surgery carries a grave prognosis, highlighting the need for preventative strategies.