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Related Experiment Videos

Modeling spatio-temporal patterns generated by Bacillus subtilis

K Kawasaki1, A Mochizuki, M Matsushita

  • 1Department of Knowledge Engineering and Computer Sciences, Doshisha University, Tanabe, Kyoto 610-03, Japan. kkawasak@doshisha.ac.jp

Journal of Theoretical Biology
|November 5, 1997
PubMed
Summary
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Bacterial colony patterns, like dense-branching morphology (DBM) and disk-like colonies, are shaped by nutrient levels and agar consistency. A new model explains these diverse bacterial growth patterns and predicts colony speed.

Area of Science:

  • Microbiology
  • Mathematical Biology
  • Biophysics

Background:

  • Bacterial colonies like Bacillus subtilis exhibit diverse morphologies on agar plates.
  • Colony patterns are influenced by environmental factors such as nutrient concentration, agar solidity, and temperature.
  • Cellular movement within colonies plays a crucial role in pattern formation.

Purpose of the Study:

  • To develop a unifying model explaining diverse bacterial colony patterns.
  • To incorporate density-dependent cell movement influenced by nutrient availability.
  • To predict colony growth velocity based on nutrient concentration.

Main Methods:

  • Development of a diffusion-reaction model.
  • Incorporation of density-dependent cell movement linked to nutrient levels.

Related Experiment Videos

  • Numerical simulations under varying environmental conditions.

    • Main Results:

    • The model successfully reproduces various colony patterns, from DBM-like to disk-like morphologies.
    • Simulations closely mimic experimental observations of bacterial colony formation.
    • The model predicts bacterial colony growth velocity as a function of nutrient concentration.

    Conclusions:

    • A single diffusion-reaction model can unify the understanding of diverse bacterial colony patterns.
    • Nutrient concentration and agar properties are key drivers of bacterial colony morphology.
    • The model provides insights into the relationship between cell behavior and macroscopic colony structures.