Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents

Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats. Adenosinergic agents such as adenosine (50, 100 mg/kg), 2-choloroadenosine (1, 2 mg/kg), carbamazepine (20, 80 mg/kg), N6-cyclohexyladenosine (1, 2 mg/kg) and dipyridamole (10, 20 mg/kg) produced theophylline-sensitive protective effects as they dose-dependently prolonged the latencies for onset of forelimb clonus with rearing. Pretreatment with Ro 5-4864 (20 mg/kg i.p.) did not offer any protection. These results indicate the possible involvement of adenosinergic mechanism in preventing lithium-pilocarpine-induced SE and mortality.