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Opioid regulation of AP-1 DNA-binding activity in NG108-15 cells under conditions of opioid-receptor adaptation
Z S Tencheva1, M M Belcheva, A A Velichkova
1Institute of Physiology, Bulgarian Academy of Science, Sofia.
Brain Research. Molecular Brain Research
|August 1, 1997
Abstract:
Opioid-receptor adaptation may lead to changes in transcriptional regulation by sequence-specific DNA-binding proteins. Gel-shift assays of nuclear extracts from NG108-15 cells revealed that an increase of AP-1 DNA-binding activity ensues under conditions previously established to induce down- or up-regulation of delta-opioid receptors.