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Updated: Jul 12, 2026

The Knob Supination Task: A Semi-automated Method for Assessing Forelimb Function in Rats
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Quantification of the hindlimb extensor thrust response in rats

J F Ross1, D E Handley, A S Fix

  • 1Human and Environmental Safety Division, Miami Valley Laboratories, Procter & Gamble Company, Cincinnati, OH 45239-8707, USA.

Neurotoxicology and Teratology
|October 6, 1997
PubMed
Summary

This study introduces a new method to measure the extensor thrust response (ETR) in rats. The extensor thrust response (ETR) shows sensitivity to neurotoxicants, offering a distinct measure from grip strength.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Animal Models

Background:

  • The extensor thrust response (ETR) is a quantifiable measure of hindlimb muscle function.
  • Existing methods for assessing neurotoxicity often lack sensitivity to early functional changes.

Purpose of the Study:

  • To describe and validate a novel procedure for measuring the extensor thrust response (ETR) in rats.
  • To assess the utility of ETR as a functional endpoint in neurotoxicity studies.

Main Methods:

  • Developed a method to elicit and measure ETR using a digital force gauge.
  • Administered chlorpromazine (CPZ) and amphetamine (AMP) to assess acute drug effects on ETR and grip strength.
  • Conducted an 8-week study with acrylamide (ACR) exposure to evaluate chronic effects on ETR, grip strength, and neurophysiology.

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Last Updated: Jul 12, 2026

The Knob Supination Task: A Semi-automated Method for Assessing Forelimb Function in Rats
09:26

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Published on: September 28, 2017

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Main Results:

  • Chlorpromazine decreased both ETR and grip strength. Amphetamine increased grip strength but decreased ETR.
  • Acrylamide exposure led to a progressive decrease in ETR starting at 3 weeks, preceding grip strength reduction at 7 weeks.
  • ETR deficits occurred without electrophysiological abnormalities but with reduced nerve conduction velocity.

Conclusions:

  • The ETR is a reliable functional measure for both acute and repeated-dose neurotoxicity assessments.
  • ETR provides distinct information compared to grip strength and may detect early somatosensory deficits caused by neurotoxicants.