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[Sex differences in angina pectoris; a literature study]

A L Lagro-Janssen1, J A Meulenbroek

  • 1Katholieke Universiteit, vakgroep Huisartsgeneeskunde, Sociale Geneeskunde en Verpleeghuisgeneeskunde, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde
|June 28, 1997
PubMed
Summary

Angina pectoris affects men and women equally in frequency. However, women experience better prognosis with lower mortality rates and less frequent myocardial infarction development.

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Area of Science:

  • Cardiology
  • General Practice
  • Epidemiology

Context:

  • Investigating sex-based disparities in cardiovascular disease presentation and outcomes.
  • Focus on angina pectoris, a common manifestation of coronary artery disease.
  • Utilizing literature reviews and Dutch general practice registration data.

Purpose:

  • To compare the frequency, presentation, and clinical course of angina pectoris between males and females.
  • To identify potential differences in the initial manifestation of cardiovascular disease.
  • To assess sex-specific prognosis and mortality associated with angina pectoris.

Summary:

  • Angina pectoris incidence and prevalence are similar in both sexes.
  • Females tend to be diagnosed approximately 10 years later than males.
  • Females are more likely to present with angina pectoris as their first cardiovascular event, unlike males who more frequently present with myocardial infarction.
  • The clinical course of angina pectoris is more favorable in females, with lower rates of subsequent myocardial infarction and reduced mortality at 5 and 9 years.

Impact:

  • Highlights the importance of considering sex-specific factors in the diagnosis and management of angina pectoris.
  • Suggests potential differences in disease pathways or healthcare-seeking behaviors between sexes.
  • Informs clinical practice regarding risk stratification and long-term patient outcomes for angina pectoris.

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