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[Accident during retinal fluorescein angiography]
Minerva Anestesiologica
|April 1, 1997
Summary
Fluorescein angiography adverse reactions are common but mostly mild, particularly in patients with prior reactions or allergies. Severe reactions are rare, necessitating careful patient selection and adequately equipped facilities for fluorescein angiography.
Area of Science:
- Ophthalmology
- Medical Imaging
- Pharmacovigilance
Context:
- Fluorescein angiography (ARF) is a common diagnostic procedure in ophthalmology.
- Understanding the frequency and nature of adverse reactions is crucial for patient safety.
- Previous studies have indicated potential risks associated with fluorescein administration.
Purpose:
- To determine the frequency of adverse reactions following intravenous fluorescein administration during ARF.
- To identify patient-specific risk factors associated with adverse events.
- To evaluate the severity and management of reported adverse reactions.
Summary:
- A retrospective study analyzed 10,003 ARF procedures in 6524 patients.
- Adverse reactions occurred in 7.5% of patients, predominantly mild (nausea, vasovagal phenomena, anaphylactoid reactions).
- Higher risk was observed in patients with a history of previous ARF or positive allergic history; severe reactions were rare (0.27%).
Impact:
- Identifies patient groups at increased risk for mild adverse reactions during ARF.
- Highlights the generally low incidence of severe adverse events requiring intervention.
- Recommends performing ARF in a well-equipped setting to manage potential complications.
- Informs clinical practice regarding patient counseling and procedural safety measures.