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[Estrogen therapy in women with postmenopausal osteoporosis]
R Zarcone1, E Carfora, F Sergio
1Istituto di Ostetricia e Ginecologia, II Università degli Studi, Napoli.
Minerva Ginecologica
|July 1, 1997
Abstract
Background:
The effects of estrogen-therapy on bone mineral density and the incidence of fractures in 132 women with postmenopausal osteoporosis have been studied.
Materials And Methods:
The patients were randomly assigned to receive placebo or estrogens (0.15 or 0.3 or 0.625 mg) for 64 months. Bone mineral density of the lumbar spine was measured by dual-energy X-ray absorptiometry with the use of Hologic QR-1000 densitometers, in all women.
Results:
A significant increase in bone mineral density was observed in women receiving estrogens, whereas in those receiving placebo there was a decrease in bone mineral density.