Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Patch test reactions to human dander in atopic dermatitis

M Uehara, S Ofuji

    Archives of Dermatology
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of the COVID-19 pandemic on the incidence of surgical site infection after orthopaedic surgery: an interrupted time series analysis of the nationwide surveillance database in Japan.

    The Journal of hospital infection·2023
    Same author

    Thoracic aortic aneurysm is an independent factor associated with diffuse idiopathic skeletal hyperostosis.

    The bone & joint journal·2018
    Same author

    A spinner magnetometer for large Apollo lunar samples.

    The Review of scientific instruments·2017
    Same author

    Novel Application of Localized Nanodelivery of Anti-Interleukin-6 Protects Organ Transplant From Ischemia-Reperfusion Injuries.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
    Same author

    Rotatable Offner imaging system for ellipsometric measurement.

    The Review of scientific instruments·2017
    Same author

    Testing the Efficacy of Contrast-Enhanced Ultrasound in Detecting Transplant Rejection Using a Murine Model of Heart Transplantation.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016

    Patients with atopic dermatitis showed a high rate of positive patch tests to human dander. This suggests a potential contact hypersensitivity to dander in some atopic dermatitis patients.

    Area of Science:

    • Immunology
    • Dermatology
    • Allergology

    Background:

    • Atopic dermatitis is a common inflammatory skin condition.
    • The role of environmental allergens in atopic dermatitis pathogenesis is complex.
    • Human dander as a potential allergen in atopic dermatitis requires further investigation.

    Purpose of the Study:

    • To investigate the prevalence of patch test reactions to human dander in patients with atopic dermatitis.
    • To compare these reactions with those in patients with allergic contact dermatitis and healthy controls.
    • To explore the correlation between patch test and intradermal test reactions to human dander.

    Main Methods:

    • Patch testing with human dander was performed on 181 patients with atopic dermatitis, 28 with allergic contact dermatitis, and 31 healthy controls.

    Related Experiment Videos

  • Histopathological examination of positive reactions was conducted.
  • Correlation analysis was performed between patch test and intradermal test results.

    • Main Results:

    • A significantly higher frequency of positive patch test reactions to human dander was observed in atopic dermatitis patients (66%) compared to allergic contact dermatitis patients (7%) and controls (3%).
    • Positive reactions presented as erythema and papules with eczematous changes around hair follicles.
    • A significant correlation existed between patch test and intradermal test reactions to human dander in atopic patients.

    Conclusions:

    • Certain patients with atopic dermatitis may exhibit contact hypersensitivity to human dander.
    • The findings suggest human dander as a potential allergen in atopic dermatitis.
    • Further research is needed to determine the role of this hypersensitivity in the pathogenesis of atopic dermatitis.