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[Immunogenetic study in Mexican couples with recurrent spontaneous abortions]
B Silva1, J K Yamamoto-Furusho, P Grether
1Departamento de Genética, Hospital General de México, SS, México, D.F.
Aim:
To study the HLA markers in Mexican couples who have suffered three or more spontaneous abortions.
Design:
The study included 24 couples with recurrent abortions and 32 with normal fertility.
Method:
HLA class I (A, B, C) and class II (DR, DQ) typing was done with a standard microlymphocytoxity test. The intergroup differences were evaluated by chi-square and the Fisher exact test.
Results:
The frequency of the MHC markers in the males and females of couples with abortions were not significantly different from those in fertile couples. However, the abortion couples shared class I antigens more often than expected from random mating as compared to fertile couples, specially in the HLA-B locus. We also found a significantly decreased frequency of the HLA-B7 antigen in males belonging to the abortion group.
Conclusion:
These results suggest that HLA-B antigens may be markers for genes related to pregnancy outcome in Mexicans.