Related Experiment Videos
[Fluconazole in meningeal coccidioidomycosis]
J J Ayala-Gaytán1, B A Condarco-Cortés, J A Pérez-Zuno
1Servicios de Infectología, Instituto Mexicano del Seguro Social, Monterrey, N.L.
Summary
Fluconazole effectively treated coccidioidal meningitis in ten patients, including children and adults. While some cases relapsed after discontinuation, they responded well to retreatment, indicating fluconazole
Area of Science:
- Mycology
- Infectious Diseases
- Clinical Pharmacology
Context:
- Coccidioidal meningitis is a serious fungal infection of the central nervous system.
- Treatment options for coccidioidal meningitis have historically presented challenges.
- Experience with fluconazole in pediatric and adult coccidioidal meningitis is reported.
Purpose:
- To evaluate the efficacy and safety of fluconazole in treating coccidioidal meningitis.
- To assess treatment outcomes in both pediatric and adult patient populations.
Summary:
- Ten treatment-naive patients (5 children, 5 adults) with coccidioidal meningitis received fluconazole.
- Cerebrospinal fluid cultures confirmed the diagnosis.
- Patients received fluconazole (6 mg/kg/day for children, 400 mg/day for adults); all responded well initially. Five patients discontinued treatment, and four relapsed but responded to retreatment.
Impact:
- Fluconazole demonstrates utility as a treatment for coccidioidal meningitis.
- The study provides valuable clinical data on fluconazole dosing and outcomes in a mixed-age cohort.
- Findings support the role of fluconazole in managing this severe fungal infection.