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Fundic gland polyps developing during omeprazole therapy
H M el-Zimaity1, F W Jackson, D Y Graham
1Baylor College of Medicine, VAMC, Houston, Texas, USA.
The American Journal of Gastroenterology
|October 23, 1997
Summary
Omeprazole use may cause fundic gland polyps, even without H. pylori infection. This study describes six cases of these polyps developing during omeprazole therapy for Barrett's esophagus.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Omeprazole therapy can cause hypergastrinemia and gastric changes.
- Fundic gland polyps are a potential side effect, particularly in patients with H. pylori infection.
Purpose of the Study:
- To report six cases of fundic gland polyps developing during omeprazole treatment for Barrett's esophagus.
- To investigate the relationship between omeprazole use and fundic gland polyp formation in the absence of H. pylori.
Main Methods:
- Retrospective analysis of six patients treated with omeprazole (20 mg/day) for Barrett's esophagus.
- Clinical follow-up and histological examination of fundic polyps.
- Assessment of H. pylori status and serum gastrin levels.
Main Results:
- Fundic gland polyps developed in six patients after 1-5 years of omeprazole therapy.
- Histology confirmed characteristic fundic gland polyps with cystic dilations.
- None of the patients had H. pylori infection; serum gastrin levels were normal or slightly elevated.
Conclusions:
- The findings suggest a possible causal link between omeprazole use and fundic gland polyps.
- This association may occur in patients without H. pylori-associated gastritis.
- Further research is warranted to elucidate the mechanism and clinical significance.