Related Experiment Videos
Long-term survival in an HIV-infected renal transplant recipient
T S Ahuja1, B Zingman, D Glicklich
1Department of Medicine, Montefiore Medical Center, Bronx, N.Y. 10467, USA.
Insights
This case study highlights a renal transplant recipient who survived over 9 years post-transplant with HIV-1 infection, managing infectious complications. It reviews other long-term organ transplant survivors with HIV and discusses immunosuppressive drug effects on HIV expression.
Area of Science:
- Immunology
- Virology
- Transplantation Medicine
Background:
- Review of long-term outcomes for solid organ transplant recipients with Human Immunodeficiency Virus (HIV).
- Focus on infectious complications and survival rates in HIV-positive transplant patients.
Observation:
- A 46-year-old male renal transplant recipient (post-1984) contracted HIV-1 in 1986.
- Experienced infectious complications starting 19 months post-transplant.
- Survived for 109 months post-transplant before succumbing to sepsis.
Findings:
- Demonstrates prolonged survival (over 9 years) in an HIV-1 infected renal transplant recipient despite infectious complications.
- Highlights the successful management of infections in this long-term survivor.
- Suggests potential influence of immunosuppressive agents like prednisone and cyclosporine on HIV-1 expression.
Implications:
- Provides insights into the long-term prognosis and management strategies for HIV-infected solid organ transplant recipients.
- Underscores the importance of managing opportunistic infections in immunocompromised HIV patients.
- Warrants further investigation into the interaction between immunosuppression and HIV replication in transplant settings.
Abstract:
A 46-year-old Hispanic male with a history of intravenous drug abuse and sexual promiscuity received a cadaveric renal transplant in January 1984. He tested positive for HIV- 1 in February 1986. Infectious complications began 19 months after transplantation and were managed successfully until his death from sepsis 109 months posttransplant. Other HIV-infected long-term solid organ transplant survivors are reviewed from the literature. The effects of prednisone and cyclosporine on HIV- 1 expression are discussed briefly.