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Related Experiment Videos

Neomycin toxicity revisited

H Masur, P K Whelton, A Whelton

Archives of Surgery (Chicago, Ill. : 1960)

|July 1, 1976

Summary

This summary is machine-generated.

Neomycin sulfate, used topically, can cause severe kidney damage and hearing loss. A patient developed renal failure and deafness after surgical cavity lavage, highlighting absorption risks.

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Area of Science:

Nephrology
Ototoxicology
Pharmacology

Background:

Neomycin sulfate is associated with nephrotoxicity and ototoxicity.
Clinical use is restricted to topical, irrigant, and bowel sterilization to minimize risks.

Observation:

A 69-year-old patient experienced acute renal failure and total deafness.
This occurred after intermittent seven-day surgical cavity lavage with neomycin.

Findings:

Peritoneal dialysis reversed renal failure but not deafness.
Systemic absorption of neomycin following irrigant use can lead to renal failure and hearing loss.

Implications:

Neomycin irrigant solutions pose a risk of systemic absorption.
While renal failure is often reversible, neomycin-induced hearing loss is frequently permanent.