Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Limb development: marginal fringe benefits

S S Blair1

  • 1Department of Zoology, 250 N. Mills St., University of Wisconsin, Madison 53706, USA.

Current Biology : CB
|February 28, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell lineage: compartments and Capricious.

Current biology : CB·2001
Same author

Wnts, signaling and sulfates.

Science's STKE : signal transduction knowledge environment·2001
Same author

Notch signaling: Fringe really is a glycosyltransferase.

Current biology : CB·2000
Same author

Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila.

Development (Cambridge, England)·2000
Same author

Dorsoventral lineage restriction in wing imaginal discs requires Notch.

Nature·1999
Same author

Eye development: Notch lends a handedness.

Current biology : CB·1999

The pioneer protein Fringe controls how the Notch pathway responds to signals in developing Drosophila wings. This mechanism may explain how Fringe-like molecules regulate patterning in both flies and vertebrates.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The Notch signaling pathway is crucial for cell-fate determination and tissue patterning.
  • The secreted protein Fringe is known to influence Notch signaling.
  • Understanding Fringe's precise role in ligand sensitivity is key to deciphering developmental processes.

Purpose of the Study:

  • To investigate the function of the pioneer protein Fringe in regulating Notch signaling pathway sensitivity.
  • To elucidate the mechanism by which Fringe modulates responses to different Notch ligands.
  • To explore the conserved role of Fringe-like molecules in developmental patterning.

Main Methods:

  • Utilizing Drosophila wing development as a model system.
  • Analyzing the effects of Fringe on Notch pathway activation in response to various ligands.

Related Experiment Videos

  • Employing genetic and molecular techniques to study protein-ligand interactions.

    • Main Results:

    • Fringe was shown to regulate the sensitivity of the Notch signaling pathway to distinct ligands.
    • This regulation was observed in the context of developing Drosophila wings.
    • Evidence suggests a conserved mechanism for Fringe-like molecules in patterning.

    Conclusions:

    • Fringe acts as a key regulator of Notch pathway sensitivity to ligands during development.
    • The identified mechanism provides insights into how Fringe-like proteins control tissue patterning.
    • This finding has implications for understanding developmental processes in both Drosophila and vertebrates.