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Transcription control: repressed repeats express themselves
1Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892-5431, USA. awlme@helix.nih.gov
Current Biology : CB
|February 21, 1998
Abstract:
Multi-copy transgenes are poorly expressed in plants, Drosophila and mammals; this repression is relieved by reducing copy number, leading to chromatin remodeling and transcriptional activation. Host defense mechanisms monitor repeated sequences in the genome, modulating their chromatin packaging and functional capabilities.