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Male-specific cell migration into the developing gonad

J Martineau¹, K Nordqvist, C Tilmann

¹Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Current Biology : CB

|February 21, 1998

Summary

Mesonephric cell migration into developing gonads is male-specific, requiring a Y chromosome signal. This process is crucial for initiating testis development from the indifferent gonad.

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Area of Science:

Developmental biology
Genetics
Cell biology

Background:

The Sry gene initiates testis development in mammalian embryos.
Early XY gonad development involves significant cellular reorganization.
The role of mesonephric cells in gonad development is not fully understood.

Purpose of the Study:

To investigate the contribution of mesonephric cells to gonad development.
To determine if mesonephric cell migration is sex-specific.
To identify signals that regulate mesonephric cell migration into the gonad.

Main Methods:

Grafting of wild-type mouse gonads with transgenic mesonephroi expressing beta-galactosidase.
In vitro culture of gonad-mesonephros grafts.
Histological analysis and beta-galactosidase staining to track cell origins.

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Main Results:

Mesonephric cells migrated into XY gonads but not XX gonads between 11.5-16.5 days post coitum.
Migrating mesonephric cells included endothelial cells and populations near Sertoli cells.
Cell migration was observed to be male-specific.

Conclusions:

Mesonephric cell migration to the gonad is a male-specific event.
This migration depends on a Y chromosome-dependent signal, potentially acting as a chemoattractant.
Mesonephric cell infiltration may be critical for initiating testis development.