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Apolipoprotein E polymorphism in the Greek population

E Sklavounou¹, E Economou-Petersen, G Karadima

¹Department of Chemistry, University of Athens, Greece.

Clinical Genetics

|January 24, 1998

Summary

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This study analyzed Apolipoprotein E (APOE) allele frequencies in Greeks. The APOE epsilon4 allele, linked to health risks, was found at a low frequency of 6.5% in this population.

Area of Science:

Genetics and Human Health
Population Genetics
Cardiovascular and Neurological Disease Research

Background:

The Apolipoprotein E (APOE) gene, located on chromosome 19, has three common alleles: epsilon2, epsilon3, and epsilon4.
The APOE epsilon4 allele is a known risk factor for increased plasma cholesterol, atherosclerosis, cardiovascular disease, Alzheimer's disease, and reduced longevity.

Purpose of the Study:

To determine the distribution and frequency of APOE alleles within the Greek population.
To compare the Greek APOE allele frequencies with global data, particularly concerning the at-risk epsilon4 allele.

Main Methods:

DNA analysis was performed on a cohort of 216 healthy Greek blood donors (146 males, 70 females).
Allele frequencies for APOE epsilon2, epsilon3, and epsilon4 were calculated based on the DNA analysis results.

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Main Results:

The APOE allele frequencies in the Greek population were determined as follows: epsilon2: 5.3%, epsilon3: 88.2%, and epsilon4: 6.5%.
The frequency of the APOE epsilon4 allele in the Greek population (6.5%) is among the lowest reported globally, comparable to frequencies observed in the Chinese population.

Conclusions:

The Greek population exhibits a low frequency of the APOE epsilon4 allele.
This finding suggests a potentially lower genetic predisposition to APOE epsilon4-associated diseases within the Greek population compared to other global populations.