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Related Experiment Videos

Malnutrition and experimental lung allergy

M G Cunha1, C K Naspitz, F Macedo-Soares

  • 1Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Brazil.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|December 31, 1997
PubMed
Summary

Protein-calorie malnutrition in rats significantly reduces allergic lung inflammation by lowering anaphylactic antibody levels. This suggests malnutrition impacts antibody production, not mediator release or vascular response, in allergic reactions.

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Area of Science:

  • Immunology
  • Nutrition Science
  • Allergic Diseases

Background:

  • Immune responses are known to be affected by malnutrition.
  • Limited data exists on malnutrition's impact on allergic diseases.

Purpose of the Study:

  • To investigate the effect of protein-calorie malnutrition on allergic lung inflammation in a rat model.

Main Methods:

  • Anaphylactic reactions were induced in rat lungs.
  • Vascular permeability was measured using the Evans blue extravasation method.
  • Two dietary groups were studied: normoproteic (18% protein) and hypoproteic (4.5% protein), inducing severe malnutrition.

Main Results:

  • Malnourished rats showed significantly lower allergic lung inflammation and vascular permeability.

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  • Serum IgE levels were significantly reduced in malnourished rats.
  • Passive antibody transfer restored the allergic response intensity in malnourished rats.

    • Conclusions:

    • Protein-calorie malnutrition diminishes allergic lung inflammation primarily by reducing anaphylactic antibody production.
    • The capacity to release inflammatory mediators and vascular response to them are not affected by this malnutrition.
    • Lowered antibody levels are the likely cause of the reduced airway response in malnourished animals.