Related Experiment Videos
New insight into the catalytic mechanism of chorismate mutases from structural studies
A Y Lee1, J D Stewart, J Clardy
1Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, USA.
Chemistry & Biology
|April 1, 1995
Abstract:
Chorismate mutase catalyzes the rearrangement of chorismic acid to prephenic acid, which is the first committed step in the biosynthesis of aromatic amino acids. Its catalytic mechanism has been much studied, but is poorly understood. Recent structural information on enzymes from two species, and on an antibody that catalyzes the same reaction, has shed new light on this topic.