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Charged with meaning: the structure and mechanism of phosphoprotein phosphatases
1Department of Chemistry, Indiana University, Bloomington 47405, USA.
Chemistry & Biology
|November 1, 1995
Abstract:
Many phosphatases require two metal ions for catalysis. New structural information on two serine/threonine phosphatases offers insight into how the metals contribute to catalysis. A comparison with the structures of protein tyrosine phosphatases, which do not use metal ions, shows that the only similarity at the active site is that of charge.