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Related Experiment Videos

Progress in antisense therapeutics discovery and development

S T Crooke1

  • 1Isis Pharmaceuticals Inc., Carlsbad Research Center, CA 92008, USA.

Ciba Foundation Symposium
|January 1, 1997
PubMed
Summary
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Antisense therapeutics, including phosphorothioate oligonucleotides, are rapidly advancing. New chemical classes are emerging, enhancing the development of these innovative drugs for clinical trials.

Area of Science:

  • Pharmacology
  • Drug Development
  • Molecular Biology

Background:

  • Antisense therapeutics represent a rapidly evolving field in drug discovery.
  • Phosphorothioate oligonucleotides (PS-ONs) are a key class of antisense drugs with established properties.
  • Significant advancements in understanding PS-ONs are crucial for therapeutic progress.

Purpose of the Study:

  • To summarize the current progress in antisense therapeutic development.
  • To highlight the available knowledge on pharmacokinetic, toxicological, and pharmacological properties of PS-ONs.
  • To discuss emerging chemical classes of antisense drugs advancing towards clinical trials.

Main Methods:

  • Literature review and synthesis of existing data on antisense therapeutics.

Related Experiment Videos

  • Analysis of pharmacokinetic, toxicological, and pharmacological profiles of PS-ONs.
  • Identification and characterization of novel chemical entities for antisense drug development.

    • Main Results:

    • Comprehensive understanding of PS-ON properties is now available.
    • New and improved chemical classes of antisense drugs are under active investigation.
    • These novel agents are progressing towards clinical evaluation.

    Conclusions:

    • The field of antisense therapeutics is experiencing rapid advancement.
    • Detailed knowledge of PS-ONs supports their continued development.
    • Emerging chemical classes promise expanded therapeutic options and clinical applications.