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Effects of a thromboxane A2 receptor antagonist in an animal model of inflammatory bowel disease
T Taniguchi1, H Tsukada, H Nakamura
1Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan.
Background/Aims:
We evaluated the effects of an antagonist of the thromboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bowel disease (IBD).
Methods:
Colitis was induced by intracolonic instillation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ONO-NT-126 or vehicle alone was administered intraluminally via anus once a day. The rats were killed after 7 days for assessment of colonic damage by the colonic damage score.
Results And Conclusion:
ONO-NT-126 markedly reduced the colonic damage. Our findings suggest that the thromboxane-thromboxane receptor system plays an important role in this model of IBD and that antagonism of the thromboxane A2 receptor may prove useful for the treatment of IBD.