Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

von Willebrand factor: biological function and molecular defects

P Perutelli1, P Biglino, P G Mori

  • 1Hematology and Oncology Department, G. Gaslini Children's Hospital, Genova, Italy.

Pediatric Hematology and Oncology
|December 31, 1997
PubMed
Summary

Von Willebrand factor (vWF) is crucial for blood clotting and preventing bleeding disorders. Recent advances clarify vWF structure-function, molecular defects, and von Willebrand disease (vWD) classification.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

von Willebrand factor, von Willebrand factor-cleaving protease, and shear stress.

Cardiovascular & hematological agents in medicinal chemistry·2007
Same author

Identifying carriers of type 2N von Willebrand disease: procedures and significance.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2007
Same author

Mutation analysis is an essential strategy in the genetic counselling of sporadic haemophilia B families.

Haemophilia : the official journal of the World Federation of Hemophilia·2002
Same author

Adhesion of MNC to extracellular matrix proteins following in vitro photochemotherapy.

Cytotherapy·2002
Same author

[Recovery of transplantable hematopoietic progenitor cells from the umbilical cord blood].

Recenti progressi in medicina·2002
Same author

A new strategy for prenatal diagnosis in a sporadic haemophilia B family.

Haemophilia : the official journal of the World Federation of Hemophilia·2001

Area of Science:

  • Biochemistry
  • Hematology
  • Molecular Biology

Background:

  • Von Willebrand factor (vWF) is essential for hemostasis, mediating platelet adhesion and stabilizing Factor VIII.
  • vWF's multimeric structure and distinct molecular domains dictate its ligand-binding specificity and affinity.
  • Abnormalities in vWF cause von Willebrand disease (vWD), the most common inherited bleeding disorder.

Purpose of the Study:

  • To review recent advancements in understanding vWF structure-function relationships.
  • To discuss updated methods for detecting molecular defects in vWD.
  • To highlight the revised classification of von Willebrand disease.

Main Methods:

  • Literature review of recent research on vWF.
  • Analysis of studies on vWF molecular structure and function.

Related Experiment Videos

  • Examination of diagnostic techniques for vWD.

    • Main Results:

    • Elucidation of specific vWF domains responsible for ligand binding and multimerization.
    • Identification of key molecular defects associated with different vWD types.
    • Progress in diagnostic strategies for vWD detection.

    Conclusions:

    • Understanding vWF structure-function is key to diagnosing and managing vWD.
    • Advances in molecular diagnostics are improving vWD detection and classification.
    • The revised vWD classification reflects a better understanding of the disease's molecular basis.