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The human cornea has a high incidence of acquired chromosome abnormalities
M J Pettenati1, A J Sweatt, P Lantz
1Department of Pediatrics, Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA.
Human Genetics
|January 7, 1998
Abstract:
Structurally and functionally, the human cornea is a highly specialized tissue. The corneal stromal collagen matrix is uniquely transparent and yet maintains a mechanically tough and chemically impermeable barrier between the eye and environment. We report for the first time that stromal keratocytes of the human cornea show cytogenetic abnormalities with a frequency that is unprecedented among normal tissues. The abnormalities are acquired, clonal and nonclonal, primarily aneuploid in nature, and present in normal as well as diseased corneas.