Tissue engineering and the development of Apligraf, a human skin equivalent

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Generation of Self-assembled Vascularized Human Skin Equivalents
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Generation of Self-assembled Vascularized Human Skin Equivalents

Published on: February 12, 2021

W H Eaglstein1, V Falanga

  • 1Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida, USA.

Clinical Therapeutics
|January 7, 1998
PubMed

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...