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Related Experiment Videos

Cefaclor therapy in uncomplicated cystitis

K Asvanich1, V Fugpholngam, S Srimuang

  • 1Department of Family Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|February 12, 1998
PubMed
Summary

Cefaclor effectively treated acute urinary tract infections in 97% of patients, eradicating pathogens in 90%. This antibiotic showed activity against common urinary pathogens like E. coli with no observed adverse effects.

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Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Urology

Background:

  • Urinary tract infections (UTIs) are common bacterial infections requiring effective antibiotic treatment.
  • Enterobacteriaceae, including Escherichia coli and Klebsiella species, are primary causative agents of UTIs.
  • Assessing the efficacy and safety of antibiotics like cefaclor is crucial for managing UTIs.

Purpose of the Study:

  • To evaluate the clinical efficacy and pathogen eradication rates of oral cefaclor in patients with acute UTIs.
  • To determine the in vivo activity of cefaclor against common Enterobacteriaceae causing UTIs.
  • To assess the safety and tolerability of cefaclor treatment in this patient cohort.

Main Methods:

  • A study involving thirty patients diagnosed with acute urinary tract infections.

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  • Patients received oral cefaclor at a dosage of 500 mg three times daily for seven days.
  • Urine cultures were performed pre-treatment and post-therapy to assess bacterial eradication.

    • Main Results:

    • Clinical success was observed in 97% (29/30) of patients treated with cefaclor.
    • Pathogen eradication was achieved in 90% (27/30) of the study participants.
    • Cefaclor demonstrated continued activity against key Enterobacteriaceae, including Escherichia coli and Klebsiella species.

    Conclusions:

    • Oral cefaclor is a highly effective treatment for acute urinary tract infections.
    • The antibiotic demonstrates significant pathogen eradication capabilities and a favorable safety profile.
    • Cefaclor remains a viable therapeutic option against prevalent Enterobacteriaceae responsible for UTIs.