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P53 gene product and EGF-receptor are highly expressed in placental site trophoblastic tumor
J Müller-Höcker1, N Obernitz, A Johannes
1Pathologisches Institut, Ludwig-Maximilians-Universität, München, Germany.
Human Pathology
|December 31, 1997
Abstract:
Immunohistochemical analysis of curettage material from a placental site trophoblastic tumor (PSTT) revealed a high expression of p53 gene products, of epidermal growth factor receptor (EGF-R) and of Ki-67 (MIB-1) proliferation associated antigen. bcl-2 was not expressed. These results show that in PSTT inactivation/dysregulation of p53 and upregulation of EGF-R and MiB-1 occurs, indicating that these factors are probably involved in tumor genesis and propagation of PSTT. The prognostic significance of the molecular genetic data, however, remains to be established.